HepSeq is a repository for an extensive library of public health and molecular data relating to hepatitis B virus (HBV) infection collected from international sources. It is hosted by the Centre for Infections, Health Protection Agency (HPA), England, United Kingdom. This repository has been developed as a web-enabled, quality-controlled database to act as a tool for surveillance, HBV case management and for research. The web front end for the database system can be accessed from http://www.hpa-bioinfodatabases.org.uk/hepatitis_open/main.php.
The format of the database system allows for comprehensive curated data to be deposited into a functional database, to effect customised searches, and to extract and visualise the information. Specific tools, built into the database, can be utilised to analyse deposited data and provide information on HBV genotype, identify mutations with known clinical significance (eg vaccine escape, precore and antiviral resistant mutations) and carry out sequence homology searches against other deposited strains.
Recent develoments :
HBV genotyping methodology is improved with confidence flags derived from statistical analysis.
New sequence annotation tool with features such as specific mutational sites and antigenic epitopes is implemented.
HepSeq project is funded by the UK Department of Health.
1. Gnaneshan, S., Ijaz, S., Moran, J., Ramsay, M. and Green, J. (2007) HepSeq - International Public Health Repository for Hepatitis B. Nucleic Acids Res. 35: in press.