The dog genome project is a collaborative study aimed at producing a map of all of the chromosomes in dogs, which can be used to map the genes causing disease and those genes controlling morphology and behavior.
The SNPSTR database contains the SNP-STR/microsatellite compound markers in the five model species, where sufficient SNP information exists in both of the NCBI and Ensembl databases. These species are human (Homo sapiens), mouse (Mus musculus), rat (Rattus norvegicus), dog (Canis familiaris) and chicken (Gallus gallus).
The authors gratefully acknowledge financial support from the Wellcome Trust.
The Exon-Intron Database (EID), publicly available since 2000, is a flat-file, Fasta-formated collection of sequences and annotations for all exons and introns obtained from GenBank. The primary goal of EID is to offer a comprehensive and convenient dataset of sequences for computational biologists who study exon-intron gene structures and pre-mRNA splicing. New innovations in EID have been implemented in 2005. The collection of exons and introns has been extended beyond coding regions and current versions of EID contain data on untranslated regions of gene sequences as well. Intron-less genes are included as a special part of EID. For species with entirely sequenced genomes, species-specific databases have been generated. Currently, these species-specific sets of all introns and all exons are available for human, mouse, rat, dog, chicken, zebrafish, fruit fly, worm (C. elegans), and mouse-ear cress (A. thaliana). This list will be extended on a monthly basis in accordance with GenBank updates. EID is freely available at http://www.meduohio.edu/bioinfo/eid/.
Recent develoments :
All recent improvements in EID are described in http://www.meduohio.edu/bioinfo/eid/word/README_Sept05.DOC
Support for this work was provided by the Medical University of Ohio Foundation and the Stranahan Foundation, through the Program in Bioinformatics and Proteomics/Genomics. We would like to thank Robert Blumenthal and Peter Bazeley, Medical University of Ohio, for discussion and suggestions on our database.
1. Saxonov, S., Daizadeh, I., Fedorov, A. and Gilbert, W. (2000) EID: The Exon-Intron Database: An exhaustive database of protein-containing genes. Nucl. Acids Res., 28, 185-190.
2. Fedorov, A., Stombaugh, J., Harr, M.W., Yu, S., Nasalean, L. and Shepelev, V. (2005) Computer identification of snoRNA genes using a Mammalian Orthologous Intron Database. Nucl. Acids Res., 33, 4578-4583.
The Centre for Applied Genomics is a Canadian centre for human genome and disease research. Resources include Genomic and cDNA library screening (human, mouse, dog, pig) provided free to Canadian academic researchers with a nominal clone retrieval fee. Also: Research Genetics, NIA/NIH and RIKEN cDNAs.