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GPCR NaVa database

http://nava.liacs.nl/

Description :
The GPCR NaVa database describes sequence variants within the family of human G Protein-Coupled Receptors (GPCRs). GPCRs regulate many physiological functions and are the targets for most of today s medicines. The acronym NaVa stands for Natural Variant, which means any (non-artificial) variant that occurs in humans.
The GPCR NaVa database includes:
1) rare mutations (frequency below 1%);
2) polymorphisms (frequency above 1%), including Single Nucleotide Polymorphisms (SNPs);
3) variants without estimates of allele frequency.
The GPCR NaVa database aids GPCR research by categorising and integrating information on variants from databases and scientific papers. Moreover, the GPCR NaVa database is linked with the reputable GPCRDB.

Aknowledgement :
The GPCR NaVa database resulted from a joint project of the Leiden Medicinal Chemistry section of the Leiden/Amsterdam Center for Drug Research (LACDR) and the Leiden Institute of Advanced Computer Science (LIACS). We are very grateful to the Nederlandse organisatie voor Wetenschappelijk Onderzoek (NWO) for providing financial support.

References :
Kazius J., Wurdinger K., van Iterson M., Kok J., Back T., and Ijzerman A.P. (2008) GPCR NaVa database: natural variants in human G protein-coupled receptors. Hum Mutat. 29(1), 39-44.

TcSNP

http://snps.tcruzi.org/

Description :
Genetic variation in Trypanosoma cruzi

VarySysDB

http://h-invitational.jp/varygene/

Description :
Various types of human gene polymorphism

MDPD

http://datam.i2r.a-star.edu.sg/mdpd/index.php

Description :
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SysPIMP

http://pimp.starflr.info/

Description :
Platform for Identifying Mutated Proteins

Rice Mutant Database

http://rmd.ncpgr.cn/

Description :
Rice mutant database

Staden Package

http://www.mrc-lmb.cam.ac.uk/pubseq/

Description :
UNIX-based tools for sequence assembly, mutation detection and sequence analysis; free for non-commercial use. Note that Staden development and support have ceased due to lack of funding, despite widespread use.

PolySearch

http://wishart.biology.ualberta.ca/polysearch

Description :
PolySearch allows users to conduct comprehensive and associative queries, such as given X, find all Y's, where X or Y can be diseases, tissues, cell compartments, gene/protein names, SNPs, mutations, drugs and metabolites. PolySearch also identifies, highlights and ranks abstracts, paragraphs or sentences.

Gramene

http://www.gramene.org/ Gramene is a curated, open-source, data resource for comparative genome analysis in the grasses. Our goal is to facilitate the study of cross-species homology relationships using information derived from public projects involved in genomic and EST sequencing, protein structure and function analysis, genetic and physical mapping, interpretation of biochemical pathways, gene and QTL localization and descriptions of phenotypic characters and mutations.

PolyDoms

http://polydoms.cchmc.org/polydoms/

Description :
PolyDoms is a database that maps human coding SNPs onto protein domains in an effort prioritize candidate mutations and polymorphisms.

SIFT

http://blocks.fhcrc.org/sift/SIFT.html

Description :
Sorting Intolerant From Tolerant (SIFT) is a sequence homology-based tool that will predict whether an amino acid substitution will affect protein function.

rSNP_Guide

http://wwwmgs.bionet.nsc.ru/mgs/systems/rsnp/

Description :
a system of databases documenting the influence of mutations in regulatory gene regions

SCMD

http://scmd.gi.k.u-tokyo.ac.jp/

Description :
The Sacharomyces Cerevisiae Morphological Database (SCMD) is a collection of micrographs of budding yeast mutants; visualization and data mining tools are provided.

HGVbase

http://hgvbase.cgb.ki.se/

Description :
Human Genome Variation database - curated; attempt to summarize all known sequence variations in the human genome, to facilitate research into how genotypes affect common diseases, drug responses, and other complex phenotypes.

International HapMap Project

http://www.nhgri.nih.gov/10001688

Description :
The haplotype map, or HapMap, is a tool that will allow researchers to find genes and genetic variations that affect health and disease.

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