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http://genomics.ornl.gov/mist Signal transduction systems link environmental stimuli with adaptive cellular responses and enable an organism to survive and adapt to changing conditions. This communication network of signaling pathways regulates critical cellular activities in all organisms from bacteria to humans. The MiST (Microbial Signal Transduction) database is a comprehensive catalog of the signal transduction proteins (two- and one-component systems) within completely sequenced bacterial and archaeal genomes. These are identified with various domain profiles that directly or indirectly implicate a particular protein as participating in signal transduction. MiST currently contains information on the signal transduction proteins within more than 365 genomes and newly, available genomes are added on a monthly basis. We have designed a user-friendly interface to facilitate the comparison and analysis of bacterial signal transduction repertoires.