Ligand-gated ion channels are polymeric transmembrane proteins involved in the fast response to numerous neurotransmitters. All these receptors are formed by homologous subunits, and the last two decades revealed an unexpected wealth of genes coding for these subunits. The Ligand Gated Ion Channel database (LGICdb) has been developed to handle this increasing amount of data. The database aims to provide a unique entry for each gene, containing annotated nucleic acid and protein sequences. The entries can be browsed by various criteria, or searched by keywords or sequence similarity. In addition to the sequences, the LGICdb provides phylogenetic analyses and atomic coordinates when available. The database is accessible via the World Wide Web where it is continuously updated. Periodic snapshots are available for download.
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