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LGICdb

http://www.ebi.ac.uk/compneur-srv/LGICdb/

Description :
Ligand-gated ion channels are polymeric transmembrane proteins involved in the fast response to numerous neurotransmitters. All these receptors are formed by homologous subunits, and the last two decades revealed an unexpected wealth of genes coding for these subunits. The Ligand Gated Ion Channel database (LGICdb) has been developed to handle this increasing amount of data. The database aims to provide a unique entry for each gene, containing annotated nucleic acid and protein sequences. The entries can be browsed by various criteria, or searched by keywords or sequence similarity. In addition to the sequences, the LGICdb provides phylogenetic analyses and atomic coordinates when available. The database is accessible via the World Wide Web where it is continuously updated. Periodic snapshots are available for download.

References :
1. Le Novere N., Changeux J.-P. (2001). LGICdb: the ligand-gated ion channel database. Nucleic Acids Research 29: 294-295.
2. Le Novere N., Changeux J.-P. (2001). The Ligand Gated Ion Channel database (LGICdb), an example of a sequence database in neuroscience. Phyl. Trans. Roy. Soc., 356: 1121-1130.
3. Le Novere N, Changeux JP (1999). The Ligand Gated Ion Channel database. Nucleic Acids Research 27: 340-342.
4. Le Novere N, Changeux JP (1995). Molecular evolution of the nicotinic acetylcholine receptor: an example of multigene family in excitable cells. Journal of Molecular Evolution 40 :155-172.

IUPHAR-DB

http://www.iuphar-db.org/

Description :
G protein coupled receptors and ion channels

VKCDB - Voltage-gated K+ Channel Database

http://vkcdb.biology.ualberta.ca/

Description :
Voltage-gated potassium channel database

References :
1. Li B, Gallin WJ. VKCDB: voltage-gated potassium channel database. BMC Bioinformatics. 2004 Jan 09;5(1):3. http://www.biomedcentral.com/1471-2105/5/3

Ligand-Gated Ion Channel Database (LGIC)

http://www.ebi.ac.uk/compneur-srv/LGICdb/LGICdb.php n the LGIC Database you will find the nucleic and proteic sequences of the subunits. Multiple sequence alignments can be generated, and some phylogenetic studies of the superfamilies are provided. Finally, the atomic coordinates of subunits, or portion of subunits, are provided when available. The LGIC Database redundancy is kept to a minimum, i.e. one entry per gene. Each entry in the database has been manually constructed and checked by a researcher of the field in order to reduce the inaccuracies to a minimum.

ION CHANNELS, TRANSMITTERS, RECEPTORS & DISEASE

http://www.neuro.wustl.edu/neuromuscular/mother/chan.html This website presents in a single page the different kind of Ion Channels and their associated diseases. The good think is that, when available, the links to the OMIM card (Online Mendelian Inheritance in Man) or to the UniProtKB/Swiss-Prot card of the proteins are provided. And at the end of the page you have a list of literature references.

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