Suggest a laboratory for FREE
DynaMo (Dynamic modeling, control and optimization of metabolic networks)
Location :INESC-ID, Lisbon, Portugal.
Project DynaMo is a three-year multidisciplinary national project that involves several institutions such as INESC-ID (Lisbon, Portugal), ITQB/UNL (Oeiras, Portugal), MDAnderson Cancer Center (Univ. of Texas, Houston, USA) and Georgia Tech (Atlanta GA, USA).
DynaMo main objectives are:
- develop and validate mathematical models and computational tools for the analysis and simulation of the dynamical behavior of complex metabolic networks.
- create control and optimization strategies to alter the fluxes and concentrations of metabolites, both transiently and at steady-state, by proposing the manipulation of enzymes gene expression
- creation of an integrative bioinformatics infrastructure to store the experimental data and to implement and deploy the algorithms developed
- acquisition of experimental in vivo metabolite concentration time series data, the creation of mutant bacterial strains with desired metabolic behavior and the experimental validation of the models previously proposed.