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Ludwig Institute for Cancer Research
Location :University of California San Diego, La Jolla, California, USA, USA.
LICR research, which can be categorized into four major disciplines, is composed of both exploratory research to generate new laboratory discoveries and by translational research conducted in close association with LICR s Clinical Trials.
Tumors arise from the accumulation of mutations that affect the amount, structure and/or function of gene products. LICR investigators are identifying genes altered by cancer, and studying the normal and altered functions of those genes. This knowledge is required to develop better cancer therapies, and better diagnostic, prognostic, and treatment strategies.
Cancerous changes resulting from genetic mutations subvert the biochemical signals that drive normal cell biology. As a result, the regulation of cellular processes such as growth, division, migration, and energy metabolism are disrupted, and tumors grow and spread. LICR investigators are examining how these regulatory controls are usurped by cancer, to elucidate how the damage to normal cellular processes can be prevented or minimized.
Tumor formation and growth, and the spread of cancer (metastasis) result from the disruption of a number of different cellular processes, such as growth, division, migration, and programmed cell death (apoptosis). LICR is employing a multi-disciplinary approach to understand the biology of normal cells, and to use this knowledge to effectively fight cancer.
The immune system has a remarkable capacity for fending off infectious diseases, and it has become clear that these same defenses can recognize and destroy cancer cells. LICR is working on treatment strategies, such as targeted antibodies and cancer vaccines, which harness the body s immune system to more effectively and specifically fight cancer cells.