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Location :Ecole Normale Superieure, Paris, France.
Activities:The availability of many genome sequences enables us to approach biological problems from an entirely new perspective. While many biological insights stem from focused or systematic experimental work, it is now also possible to answer questions through information based biology. In particular, in the Dyogen group we are interested in studying functional elements in vertebrate genomes using bioinformatics tools. To do so, we are exploiting evolutionary processes that have preserved the trace of these functionally important elements, and have allowed new ones to emerge in specific lineages. Comparative genomics is thus a key to identify their location, and to understand how they are organised. From there we would like to examine which pattern, if any, does this organisation follows. To this end, differences and similarities between genomes may again provide insights into the constraints that have shaped the distribution of functional elements relative to each other.