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Integrative Bioinformatics Inc
Location : Los Altos, California, USA.
Integrative BioInformatics provides software and expert consulting to academic and industry laboratories studying biological pathways of all kinds.
Our Chief Scientific Officer and co-founder, Dr. Robert Phair, is an internationally known expert in the area of kinetic modeling, with over 35 years of experience in the modeling of complex biological systems ranging from molecular cell biology to human physiology.
Our database-driven software, ProcessDB, brings this experience to your own lab by providing state-of-the-art tools and best practices in an intuitive software application that\'s firmly grounded in basic principles of biology and physical chemistry.
Kruhlak M, Crouch EE, Orlov M, Montano C, Gorski SA, Nussenzweig A, Misteli T, Phair RD, Casellas R.
The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks.
Nature 2007 Jun 7;447(7145):730-4. PMID: 17554310
Phair RD, Misteli T. Kinetic modelling approaches to in vivo imaging. Nature Rev Mol Cell Biol. 2001 Dec;2(12):898-907. Review. PMID: 11733769
Dundr M, Hoffmann-Rohrer U, Hu Q, Grummt I, Rothblum LI, Phair RD, Misteli T. A kinetic framework for a mammalian RNA polymerase in vivo. Science. 2002 Nov 22;298(5598):1623-6. PMID: 12446911
Presley JF, Ward TH, Pfeifer AC, Siggia ED, Phair RD, Lippincott-Schwartz J. Dissection of COPI and Arf1 dynamics in vivo and role in Golgi membrane transport. Nature. 2002 May 9;417(6885):187-93. PMID: 12000962
Phair RD, Misteli T. High mobility of proteins in the mammalian cell nucleus. Nature. 2000 Apr 6;404(6778):604-9. PMID: 10766243
Zaal KJ, Smith CL, Polishchuk RS, Altan N, Cole NB, Ellenberg J, Hirschberg K, Presley JF, Roberts TH, Siggia E, Phair RD, Lippincott-Schwartz J. Golgi membranes are absorbed into and reemerge from the ER during mitosis. Cell. 1999 Dec 10;99(6):589-601. PMID: 10612395
systems biology, kinetics, modeling, ProcessDB, cell biology, human biology, consulting